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在皮肤转移的电穿孔后,瘤环境中的免疫细胞群:一个组织病理学研究

Mille Vissing¹, Sandra Sinius Pouplier², Lars Munch Larsen³

¹Centre for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde and Næstved, Næstved, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Acta oncologica (Stockholm, Sweden)

|May 28, 2024

概括

电穿孔 (CaEP) 显示出作为一种抗瘤疗法的潜力,因引起显著的亡和减少调节性淋巴细胞,尽管瘤透性淋巴细胞 (TIL) 没有改变. 一些患者表现出免疫反应的临床迹象.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

电穿孔 (CaEP) 使用注射和电脉冲来诱导癌细胞死亡.
调查CaEP对免疫反应和皮肤转移中的组织病理变化的影响至关重要.

研究的目的:

评估使用CaEP治疗的皮肤转移患者的免疫反应和组织病理变化.
评估CaEP作为抗瘤疗法的疗效.

主要方法:

一组24名转移大于5毫米的患者接受了一次或两次CaEP治疗.
在治疗后的多个时间点收集瘤活检以进行分析.
主要终点:瘤透淋巴细胞 (TILs) 的变化;次要终点:免疫标记物,亡和炎症.

主要成果:

17名患者完成了这项研究,主要是乳腺癌转移.
CaEP诱导了大量的瘤缩,并降低了FOXP3+调节性淋巴细胞 (p=0.0025).
没有观察到TIL计数或PD-L1表达的显著变化,但四名患者显示瘤侵入性降低.

结论:

CaEP显示出作为一种具有免疫调节作用的有效抗瘤疗法的潜力.
治疗导致显著的亡和调节性淋巴细胞的减少.
在几名患者身上观察到免疫反应的临床迹象,表明治疗有前途.

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