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循环IL-35+调节性B细胞与甲状腺相关的眼睛疾病有关
Qian Li1, Cuixia Yang1, Cheng Liu2
1Department of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Immunity, inflammation and disease
|May 28, 2024
概括
甲状腺相关眼科医症 (TAO) 患者中,表达中白素-35的调节性B细胞 (Bregs) 升高,这表明它在疾病发展中发挥了作用. TAO患者的B细胞可能有受损的IL-35+Breg分化.
科学领域:
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺相关眼病 (TAO) 是一种常见的轨道疾病,病因不明.
- 调节性B细胞 (Bregs),特别是IL-35表达性Bregs (IL-35+Bregs),对于自身免疫性疾病中的免疫平衡至关重要.
- IL-35+Bregs在TAO病原发生中的作用在很大程度上仍未被探索.
研究的目的:
- 在TAO患者中调查IL-35+Bregs的频率和功能.
- 探索IL-35+Bregs作为TAO中的生物标志物或治疗点的潜力.
主要方法:
- 从36名健康人群和14名TAO患者中分离了周围血液单核细胞.
- 细胞被IL-35和CpG刺激了48小时.
- 使用流细胞计量来量化IL-35+Breg百分比.
主要成果:
- 在TAO患者中,与健康对照人群相比,观察到循环IL-35+Bregs的比例更高.
- IL-35+Bregs的发生频率与TAO疾病活性正相关.
- 虽然IL-35在健康个体中增强了IL-35+Breg的产生,但TAO患者的B细胞显示了对这种表型的差异化受损.
结论:
- IL-35+Bregs可能在TAO的发展和进展中发挥重要作用.
- 这些发现为TAO免疫病原发生提供了新的见解.
- 向IL-35+Bregs可能是TAO的未来治疗策略.
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