在青春期早期的压力后的皮质可以防止社会回避,厌恶行为,以及成年后的吗啡条件的位置偏好
Samantha O Vanderhoof1, Carly J Vincent2, Jasmin N Beaver1
1Department of Psychological Sciences, Brain Health Research Institute, Kent State University, Kent, USA.
Psychopharmacology
|May 28, 2024
概括
青春期的后应激皮质 (CORT) 管理促进了社会情绪的性,并防止了成年期的药物寻求行为. 这种干预提供了一个潜在的策略,以减轻长期的精神病和药物滥用障碍风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 青少年的压力增加了成年人对精神疾病的脆弱性.
- 成年动物的压力延迟影响包括增加焦虑类行为.
- 后应激皮质 (CORT) 给药可以防止这些成年人的影响,但其在青少年中的有效性是未知的.
研究的目的:
- 研究青少年早期压力和外源性CORT对老鼠成人社会,厌恶和寻找毒品行为的影响.
- 探索对精神病和药物滥用障碍的翻译相关性.
主要方法:
- 在压力后的24小时内,在饮用水中服用CORT (400ug/mL) (社会失败或背景恐惧调节).
- 评估了青少年和成年小鼠的社会回避,恐惧处理,安赫多尼亚和吗啡位置偏好.
- 在恐惧测试期间监测内源性皮质水平和结行为.
主要成果:
- 单次后压力CORT剂量防止了社会回避,改变了恐惧处理和成年时的无情感.
- 科尔特预防了成年期的压力强化的吗啡位偏好及其从青春期开始的潜伏期.
- 外源性CORT会使内源性皮质丸激素减弱,但不会影响结行为.
结论:
- 青少年应激后的CORT管理促进了社会情感性,并防止了寻求毒品的行为.
- 压力后皮质的升高至少提高了40天的弹性,将青春期过渡到成年期.
- 这些发现对于理解青少年压力对成人情绪和药物寻求行为的影响至关重要.
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