相关实验视频

Updated: Jun 25, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

在复发性多发性硬化症中,进展独立于复发活动:与二次进展的影响和关系

Emilio Portaccio¹, Matteo Betti², Ermelinda De Meo^2,3

¹Department of NEUROFARBA, University of Florence, Careggi University Hospital, Florence, Italy. emilio.portaccio@unifi.it.

Journal of neurology

|May 28, 2024

概括

在复发性多发性硬化症 (MS) 中,不依赖复发活动的进展 (PIRA) 推动了残疾累积. 持续的PIRA与长期残疾和向二次渐进性MS (SPMS) 过渡有关.

科学领域:

神经学神经学
免疫学免疫学免疫学
临床研究临床研究

背景情况:

复发性多发性硬化症 (MS) 的特点是不可预测的复发和渐进的残疾.
了解残疾累积,复发相关恶化 (RAW) 和复发活动独立的进展 (PIRA) 的不同途径,对于有效的MS管理至关重要.
识别这些途径的预测因素和长期后果可以为治疗策略和患者的结果提供信息.

研究的目的:

调查RAW和PIRA在复发性多发性硬化症中对确认残疾累积 (CDA) 的发生和相对贡献.
确定PIRA和RAW与向二次渐进性MS (SPMS) 过渡的关联.
分析PIRA和RAW对残疾状况的长期影响.

主要方法:

来自意大利多发性硬化综合征登记处的一大群复发性多发性硬化综合征患者 (n=16,130) 的分析,随访时间超过5年.
CDA被定义为扩展残疾状况量表 (EDSS) 评分的6个月确认增加.
后勤和多变量顺序回归模型用于评估PIRA/RAW的预测因素以及与最终EDSS和SPMS过渡的关联.

主要成果:

在11.8年的时间里,PIRA占所有CDA事件的72.3%.
持续残疾累积 (SDA) 在PIRA中比RAW (56.7%) 更频繁 (73.2%).
与不持续的PIRA (24.8%) 相比,持久的PIRA患者的SPMS过渡率 (73.2%) 显著更高. 较高的EDSS最终分数与PIRA有关.

结论:

在复发性MS中,PIRA是残疾累积的主要驱动因素.
持续的PIRA与过渡到SPMS密切相关,这表明它可能代表一个更准确的逐步阶段的定义.
这些发现强调了在MS管理中解决PIRA的重要性,以减轻长期残疾.

关键词:

多发性硬化症是多发性硬化症.进展独立于复发活动的进展.与复发相关的恶化.二次进展的二次进展.

更多相关视频

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.