在母胎胎单位的神经发育和新陈代谢
Mariana Parenti1,2, Rebecca J Schmidt3,4, Daniel J Tancredi5
1Department of Nutrition, University of California, Davis.
JAMA network open
|May 28, 2024
概括
患有自闭症谱系障碍 (ASD) 的儿童母亲的胎盘和带血清代谢与非典型的发育风险有关. 在患有自闭症家族风险较高的兄弟姐妹中,这些代谢概况显示出显著的相关性.
科学领域:
- 围产期和发育生物学
- 代谢学 代谢学 代谢学
- 神经发育障碍 神经发育障碍
背景情况:
- 孕产妇,胎盘和胎儿的新陈代谢会影响发育结果.
- 母胎胎胎代谢单元与儿童神经发育之间的相互作用,特别是自闭症谱系障碍 (ASD) 风险,仍然未得到充分研究.
研究的目的:
- 调查母胎胎儿单位内的代谢关联.
- 检查这些代谢特征与ASD儿童的年轻兄弟姐妹的神经发育结果之间的关系.
主要方法:
- 在婴儿自闭症风险标志物,学习早期迹象 (MARBLES) 队列中,对ASD儿童的年轻兄弟姐妹进行了前性队列研究.
- 对母亲第三季度血清,胎盘组织和带血清进行定量代谢学分析.
- 使用标准化措施评估的神经发育结果,并将其分类为ASD,其他非典型发展 (非TD) 或典型发展 (TD).
主要成果:
- 胎盘和带血清代谢组高度相关 (R2 = 0.75,P < .001).
- 胎盘和带血清的代谢概况与非TD风险降低有显著关联 (相对风险[RR] ≈0.13,P <.05) 但不是ASD.
- 没有发现母亲的第三季度血清代谢与其他代谢或神经发育结果之间有显著的关联.
结论:
- 胎盘和带血清的新陈代谢在具有高家族ASD风险的怀孕中高度相关.
- 这些代谢特征与后代非典型发育的风险有关.
- 对母亲-胎盘-胎儿代谢单元的进一步研究可能会为神经发育轨迹提供见解.
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