在瑞典,患有月经前障碍的妇女中死亡风险高
Marion Opatowski1, Unnur Anna Valdimarsdóttir1,2,3, Anna Sara Oberg2
1Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|May 28, 2024
概括
月经前障碍 (PMDs) 不会增加女性的整体死亡风险. 然而,被诊断患有PMD的年轻女性面临更高的死亡风险,特别是自杀,需要有针对性的预防策略.
科学领域:
- 生殖健康 生殖健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 月经前障碍 (PMDs) 显著影响全球妇女的生活质量.
- 与PMD相关的长期后果和死亡风险仍未得到充分研究.
研究的目的:
- 调查月经前疾病 (PMD) 与整体和因特定死亡率之间的关联.
- 为了确定PMD人口中的特定死亡风险和脆弱子组.
主要方法:
- 在瑞典进行了一项全国性的,基于人口的,匹配的队列研究.
- 包括67,748名患有PMD的女性和338,740名匹配的对照从2001年至2018年.
- 使用条件考克斯回归的分析,调整人口,社会经济和并发病因素.
主要成果:
- 在患有PMD的女性中没有观察到整体死亡风险增加 (aHR,0.91).
- 通过非自然原因死亡的风险增加 (aHR, 1.59),特别是自杀 (aHR, 1.92).
- 年轻女性 (25岁前确诊) 的全因死亡率 (aHR,2.51),自杀率 (aHR,3.84) 和自然死亡率 (aHR,2.59) 显著上升.
结论:
- 患有PMD的女性并不面临更高的整体过早死亡风险.
- 被诊断为PMD的年轻女性需要更密切的监测和量身定制的自杀预防策略.
- 进一步的研究和干预对于管理PMD相关的死亡风险至关重要.
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