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Updated: Jun 25, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Published on: January 26, 2018

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神经元分化需要BRAT1复合体来从染色质中去除REST

Sadat Dokaneheifard1, Helena Gomes Dos Santos1, Monica Guiselle Valencia1

  • 1Department of Human Genetics, University of Miami, Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL 33136.

Proceedings of the National Academy of Sciences of the United States of America
|May 28, 2024
PubMed
概括

BRCA1关联ATM激活器1 (BRAT1) 通过与整合器复合体相互作用来激活REST响应基因,对神经元发育至关重要. BRAT1突变破坏了这一过程,导致神经发育缺陷,并将其与神经退行性疾病联系起来.

关键词:
这就是BRAT1的意义.整合器是一个整合器.休息时间 休息时间神经元分化神经元的分化转录 转录 是一种转录.

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