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Updated: Jun 25, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
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从碳氧酸中合成N-氧糖胺,N-酸糖和活性,使用I2/PPh3进行合成

Kishor L Handore1, Heyuan Lu1, Hyeongbin Park1

  • 1Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

The Journal of organic chemistry
|May 28, 2024
PubMed
概括

一种新方法有效地利用三,和三胺从碳酸中合成可分离的活性. 这种方法为有机合成,合成和生物结合提供了一种多功能且具有成本效益的替代方案.

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During hydrolysis, the ester is first activated towards nucleophilic attack through the protonation of the carboxyl oxygen atom by the acid catalyst. The protonation makes the ester carbonyl carbon more electrophilic. In the next step, water acts as a nucleophile and adds to the...
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