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Updated: Jun 25, 2025

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从使用诱导的多能干干细胞系统来模拟 xeroderma pigmentosum 中神经退行症的多原子建模的见解

Cherif Badja1, Sophie Momen1, Gene Ching Chiek Koh1

  • 1Department of Medical Genetics, Box 238, Level 6, Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Cambridge CB2 0QQ, UK; Early Cancer Institute, Department of Oncology, Box 197, Hutchison Research Centre, Cambridge Biomedical Research Campus, Cambridge CB2 0XZ, UK.

Cell reports
|May 28, 2024
PubMed
概括

Xeroderma pigmentosum (XP) 患者由于DNA修复缺陷而表现出神经退行. 这项研究揭示了XP神经元中的氧化应激和受损蛋白质清除,为这种罕见的遗传疾病提供了潜在的治疗点.

关键词:
CP: 细胞生物学 细胞生物学科普:神经科学是什么意思造成的DNA损伤是DNA损伤.这就是为什么UPSUPSUPSUPS.这就是为什么XPXPXPX早期检测 早期检测细胞内膜网膜的应激反应应激反应这些是iPSCs.神经退行症的神经退行症氧化应激是一种氧化应激.乌比奎丁-蛋白酶体系统施罗德玛 颜料 (Xeroderma pigmentosum) 是一种红色的植物.

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