心力衰竭中的血尿/肌素比率:系统综述和元分析
Yichang Zhou1, Qin Zhao2, Zhitong Liu1
1Cardiology Rehabilitation Department, Bayannur Hospital, Bayannur City, Inner Mongolia, China.
PloS one
|May 28, 2024
概括
血尿素/肌素比率 (BCR) 显著预测心力衰竭患者的全因死亡率. 虽然这是一个有希望的指标,但需要进一步研究其在心血管死亡率和心力衰竭住院治疗中的作用.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
背景情况:
- 心力衰竭 (HF) 是全球疾病和死亡的主要原因.
- 鉴定HF患者长期结果的可靠预测因素对于临床管理至关重要.
- 血尿素/肌素比 (BCR) 是一种易于获得的生物标志物,可以提供预后见解.
研究的目的:
- 评估血尿素/肌素比率 (BCR) 对心力衰竭 (HF) 患者长期结果的预测值.
主要方法:
- 进行了全面的元分析,搜索了PubMed,EMBASE,Cochrane图书馆和科学网.
- 包括到2023年10月发表的研究,使用STATA SE 14.0.0进行统计分析.
- 涉及2036名患者的14项研究分析了BCR与全因死亡率,心血管疾病 (CVD) 死亡率和HF住院之间的关联.
主要成果:
- 升高的BCR水平与HF患者全因死亡风险增加显著相关 (HR = 1.67).
- 这种关联在急性HF和非急性HF亚组中保持一致,以及在年龄≤70岁和>70岁的患者中.
- 在本次元分析中,BCR对心血管疾病死亡率和HF住院治疗的预测价值没有得到统计支持.
结论:
- 血尿素/肌素比率 (BCR) 是心力衰竭患者所有原因死亡率的重要和有前途的预测指标.
- 需要进一步的研究来阐明BCR在其他关键结果 (如心血管疾病死亡率和HF住院治疗) 中的预测作用.
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