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Martin Gierse¹, Laurynas Dagys¹, Michael Keim¹

¹NVision Imaging Technologies GmbH, 89081, Ulm, Germany.

Angewandte Chemie (International ed. in English)

|May 28, 2024

概括

一种名为PHIP-SSD的新方法增强了分子的超极化,使用了对诱导极化 (PHIP) 和固态自旋扩散. 这种技术扩大了PHIP的适用性,用于创建各种应用的超极化化合物.

科学领域:

磁共振光谱学磁共振光谱学
超极化技术超极化技术
固态化学固态化学

背景情况:

过诱导极化 (PHIP) 提供了廉价的超极化,但由于它依赖于与H2的特定化学反应而受到限制.
现有的PHIP方法需要与气直接相互作用,这限制了它们的普遍适用性.

研究的目的:

开发一种新的方法,PHIP-SSD,以扩大PHIP超极化的范围.
为了使在初始PHIP反应中没有直接参与的目标分子的超极化.

主要方法:

使用PHIP生成一个超极化源分子 ([1-13C]-酸盐).
采用固态自旋扩散来将两极化从源向目标分子转移.
溶解极化点分子用于溶液状态的NMR应用.

主要成果:

从[1-13C]-fumarate向各种13C标记的标分子成功地证明了极化转移.
对于[1-13C]-酸,13C两极分化达到0.01%至3%.
通过简单的粉末研磨,获得了对[13C,15N2]-urea,[1-13C]-pyruvate和[1-13C]-benzoic acid的100-200倍信号增强.

结论:

通过固态旋转扩散,PHIP-SSD有效地转移超极化,扩大了PHIP的实用性.
该方法不需要特定的联合结晶,允许各种分子的轻松超极化.
基于PHIP的PHIP-SSD提出了一个基于PHIP的可访问超极化有前途的战略.

关键词:

这是NMR的NMR.过极化的超极化准气为一种气.旋转扩散扩散的作用

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