Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

JUN Specifies the Local Differentiation and Maintenance of Pro-tumoral Monocyte-Derived Macrophages.

Cancer research·2026

Same author

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026

Same author

Kidney biopsy during pregnancy: indications, complications, results and therapeutic impact.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026

Same author

Relapse risk of lupus-related serositis according to immunosuppressive therapy: a national real-world study.

RMD open·2026

Same author

Belimumab use in paediatric-onset systemic lupus erythematosus: a status report in France from a retrospective multicentre descriptive study.

Rheumatology (Oxford, England)·2026

Same author

The SjD Map: an interactive pathway tour into Sjögren's disease signalling mechanisms.

NPJ systems biology and applications·2026

Search research articles

相关实验视频

Updated: Jun 25, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

一个交互式的网络应用程序,用于探索系统性红斑狼的血液转录的多样性.

Eléonore Bettacchioli^1,2, Laurent Chiche³, Damien Chaussabel^4,5

¹B Lymphocytes, Autoimmunity and Immunotherapies, UMR 1227, Univ Brest, Inserm, Brest 29200, France.

Database : the journal of biological databases and curation

|May 28, 2024

概括

一个新的网络应用程序使系统性红斑狼 (SLE) 患者的复杂血液转录组数据可访问. 这种工具有助于研究人员探索SLE异质性,并为了解疾病提出新的假设.

更多相关视频

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

相关实验视频

Last Updated: Jun 25, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

科学领域:

免疫学免疫学免疫学
计算生物学计算生物学
基因组学就是基因组学.

背景情况:

系统免疫学方法对于理解复杂的自身免疫性疾病,如系统性红斑狼 (SLE) 至关重要.
大规模的转录组数据集存在,但研究人员往往难以访问和利用.
需要用户友好的工具来增强数据的重复使用和知识的发现在翻译研究.

研究的目的:

开发和部署一个用于探索LUPUCE队列的微阵列血液转录数据的Web应用程序.
为了促进用户与复杂数据集的交互,使SLE样本异质性和疾病参数的探索.
促进数据的再利用和SLE研究的假设生成.

主要方法:

使用BloodGen3模块库框架,分析了62名成年SLE患者157个样本 (LUPUCE队列,GSE49454) 的微阵列血液转录组数据.
开发一个网络应用程序,以呈现聚合级,模块级和基因级分析结果.
包括反映疾病活动,爆发,狼性炎,自身抗体概况和干扰素特征的数据.

主要成果:

网络应用程序允许用户根据转录基因数据探索SLE样本之间的相似性和异质性.
用户可以浏览不同的分析级别,测试假设,并生成自定义可视化,如指纹网格和热图.
该资源提供了对SLE血液转录资料及其与临床和免疫学因素的关系的见解.

结论:

开发的网络应用程序提高了研究人员对复杂的SLE转录数据的可访问性和可用性.
该工具支持探索SLE的分子景观,并促进产生新的研究假设.
该资源作为一个有价值的独立工具,用于调查SLE中的血液转录档案及其临床相关性.