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黑素对抗男性白色大鼠中由聚乙烯微塑料诱导的上腺皮质损伤

Amina A Farag¹, Heba Bayoumi², Shaimaa E Radwaan³

¹Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha City 13518, Egypt.

Ecotoxicology and environmental safety

|May 28, 2024

概括

聚乙烯微塑料 (PE-MPs) 通过破坏激素产生和增加氧化应激,引起上腺毒性. 在大鼠中,黑色素 (Mel) 治疗显著地保护了这些有害的PE-MP影响.

科学领域:

环境毒理学环境毒理学
内分泌学在内分泌学.
材料科学材料科学材料科学

背景情况:

内分泌干扰化学物质 (EDC) 破坏身体的平衡.
由于其持久性和积累,微塑料 (MP) 构成重大环境和健康风险.
上腺对EDCs的敏感性和MPs对该器官的未经探索的影响突出显示了关键的知识差距.

研究的目的:

研究聚乙烯微塑料 (PE-MPs) 的潜在上腺毒性影响.
阐明PE-MP诱导的上腺毒性背后的机制.
为了确定黑激素 (Mel) 是否可以防止PE-MP诱导的上腺毒性.

主要方法:

鼠被暴露于不同剂量的PE-MPs (3.75和15毫克/公斤) 随着或没有治疗黑色素.
评估了上腺体重,组织病理和超结构性变化.
分析了血清皮质醇,上腺皮质激素,类固醇生成相关的基因表达,氧化应激标记物,炎症标记物和亡标记物.

主要成果:

PE-MPs在上腺皮质中诱导了显著的有毒变化,包括增加上腺重量和组织病理变化.
暴露于PE-MP导致血清皮质醇降低,上腺皮质激素增加,类固醇生成基因表达改变,氧化应激升高,炎症和亡.
黑色素治疗大大改善了PE-MP诱导的毒性,显示出抗氧化,抗炎,抗丧和基因调节作用.

结论:

聚乙烯微塑料具有显著的上腺毒性作用,影响激素产生,类固醇生成,氧化平衡,炎症和亡.
观察到的毒性取决于剂量,更高度的PE-MPs会导致更严重的效应.
黑色素表现出对PE-MP诱导的上腺毒性的保护作用,这表明其潜在的治疗应用.

关键词:

上腺皮层的皮层黑色素是什么黑色素是什么黑色素是什么聚乙烯微塑料中的聚乙烯微塑料类固醇生成相关的基因超结构性变化超结构性变化

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