孕妇在怀孕和哺乳期间接触F-53B会影响男性后代的骨生长和发育
Lihua Feng1, Yuanyuan Lang1, Yueying Feng1
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, China.
Ecotoxicology and environmental safety
|May 28, 2024
概括
母亲接触 6:2 化聚甲基乙硫酸盐 (F-53B) 会损害男性后代的骨发育,导致骨质疏松症和生长障碍. 这种PFAS化学物质破坏关键的骨代谢途径,影响骨健康.
科学领域:
- 环境毒理学环境毒理学
- 发展生物学 发展生物学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 6:2 化多醇基乙烯硫酸盐 (F-53B) 是一种在工业中使用的和多醇基物质 (PFAS).
- 已知F-53B会对多种哺乳动物器官造成损伤.
- 目前尚不清楚F-53B对骨发育的影响,尤其是对母亲的暴露.
研究的目的:
- 调查母体F-53B暴露对后代骨生长和发育的影响.
- 探索F-53B对骨影响的潜在机制.
- 评估对胎儿和新生儿骨健康的潜在风险.
主要方法:
- 在怀孕和哺乳期间,C57BL/6J小鼠通过饮用水接触到不同度的F-53B (0,0.57,5.7 mg/L).
- 分析了后代的骨生长,肝功能和关键信号通路.
- 检查了骨代谢标志物,包括骨质细胞和骨质细胞活性.
主要成果:
- 母亲暴露F-53B导致肝功能受损,并降低了男性后代的胰岛素类生长因子1 (IGF-1) 分泌量.
- 骨代谢失调,骨质母细胞和骨质母细胞之间的不平衡.
- 长度骨生长受到抑制,男性后代被诱导患有骨质疏松症.
结论:
- 母亲接触F-53B会对男性后代的骨发育产生负面影响,导致骨质疏松症和矮身.
- IGF-1/OPG/RANKL/CTSK信号通路与F-53B对骨的不良影响有关.
- 这项研究强调了在关键发育时期与F-53B暴露相关的骨风险.
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