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通过关注营养因素,在亚马逊人口中预先确定唇裂的危险因素:一项病例对照研究
Cynthia S M Rocha1, Franklin S Rocha1, Lucas A O Aleixo2
1Craniofacial unit, Fundação Santa Casa de Misericórdia do Pará, Belém, Pará, Brazil.
概括
母亲的脂质摄入可能会增加唇裂 (CLP) 的风险. 低叶酸摄入量,特别是有口腔裂 (OFC) 的家族史的人,也会增加这种风险.
科学领域:
- 头骨面部的发展
- 营养科学 营养科学
- 遗传性形 遗传性形 是一种先天性形.
背景情况:
- 面腔裂 (OFC) 是最常见的头骨面部先天性形.
- 母婴饮食正在研究其在OFC发展或预防中的作用.
研究的目的:
- 为了确定母亲的营养状况是否预测亚马逊群体的唇裂 (CLP).
- 分析宏观和微量营养素对CLP倾向或保护的影响.
主要方法:
- 在分娩后3个月内采访了152名母亲 (51名有CLP后代,101名对照).
- 使用食物频率问卷来评估母亲的营养.
- 分析了与CLP发生有关的宏观和微量营养素摄入量.
主要成果:
- 较高的母体脂质摄入量与CLP相关 (p=0.01).
- 在没有家族病史的人群中,在CLP组中观察到较高的脂质 (p=0.002) 和较低的蔬菜摄入量 (p=0.037).
- 患有CLP和OFC家族史的孩子的母亲的维生素B2,B5,E和叶酸摄入量较低.
结论:
- 增加母亲的脂质摄入量与非综合征性CLP的后代的可能性更高有关.
- 低母体叶酸摄入量,特别是在有OFC病史的家庭中,会增加非综合征性CLP的风险.
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