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在阻塞性睡眠呼吸暂停患者中新型血管和炎症生物标志物的血度的变化,中风前后

Pritam Das¹, Ying Wang², Ramcharan Singh Angom¹

¹Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, Jacksonville, FL, USA.

|May 28, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 与中风有关. 像PDGF-AA,CXCL10和Ang-1这样的新生物标志物显示出预测结果和指导OSA患者治疗的希望.

科学领域:

神经科学是一个神经科学.
心血管医学心血管医学
睡眠医学睡眠医学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的疾病,与严重的心血管和脑血管疾病有关,包括中风.
大脑小血管疾病 (CSVD) 和中风是OSA的已知的并发症.

研究的目的:

确定潜在的预后性血生物标志物,用于在中风后的OSA患者的疾病进展.
评估OSA患者内皮/血管,炎症和神经轴损伤标志物的实用性.

主要方法:

敏感的ELISA免疫测试被用于测量血生物标志物.
在中风后的OSA患者 (急性脑梗塞,N=26) 和与健康对照组相比,在新诊断的OSA患者的一个子集中分析了生物标志物.
神经纤维光链 (NfL) 被评估为神经轴损伤的标志物.

主要成果:

血TNFα和NfL增加,PDGF-AA降低在中风后的OSA患者中观察到严重的白质过强度 (WMHs).
与女性相比,患有严重WMH的男性中风后OSA患者表现出CXCL10和IL-10的升高,以及降低的angiopoietin-1 (Ang-1).
与健康对照组相比,新诊断的OSA患者表现出增加的CXCL10和降低的Ang-1,这表明血管炎症和内皮完整性的改变.

结论:

血生物标志物PDGF-AA,CXCL10和Ang-1显示了OSA患者在中风前和后的潜在预后价值.
这些已识别的生物标志物可以作为替代标志物来评估OSA治疗方式的疗效.
这项研究强调了OSA患者内皮完整性变化和持续的血管炎症.

关键词:

安吉奥波伊丁-1 的使用.大脑内皮细胞是脑内皮细胞.在CXCL10中,CXCL10是CXCL10中的一个.阻塞性睡眠呼吸暂停 (SOP) 是一种阻塞性睡眠暂停.一次性中风,中风.血管炎症是一种血管炎症.

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