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在EGFR突变和EGFR野生型肺腺癌与乳头主导模式之间的临床病理学差异

Eisuke Goto¹, Tetsuro Taki², Kotaro Nomura³

¹Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East Japan; Department of Thoracic Surgery, National Cancer Center Hospital East Japan; Department of General Thoracic Surgery, Juntendo University School of Medicine, Japan.

Lung cancer (Amsterdam, Netherlands)

|May 28, 2024

概括

与表皮生长因子受体 (EGFR) 突变的乳头主要腺癌 (PPA) 相比,与野生型 (WT) PPA相比,其存活率更差, galectin-3表达率更高. 这突显了肺腺癌亚型之间的关键差异.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

肺腺癌 (LUAD) 包含不同分子形状的各种亚型.
表皮生长因子受体 (EGFR) 突变是LUAD的一个子集中的关键驱动因素.
了解EGFR突变与野生型 (WT) LUAD的亚型特异性差异对于向治疗至关重要.

研究的目的:

调查EGFR突变和WT LUAD之间的临床病理和预后差异,重点关注主要的亚型.
分析与LUAD中的EGFR突变相关的基因表达模式.
评估加勒-3在EGFR突变的乳头主要腺癌 (PPA) 中的作用.

主要方法:

对352名EGFR突变患者和370名WTI阶段LUAD患者的回顾性分析.
癌症基因组图谱计划 (TCGA) 队列对基因表达差异的分析.
在46名EGFR突变患者和47名WT PPA患者中对加列-3的免疫组织化学评估.

主要成果:

与WT PPA相比,EGFR突变的PPA具有较小的侵入性尺寸和较少的船只入侵.
经EGFR突变的PPA的5年无复发存活率 (70.6%) 比WT PPA (83.3%) 明显更差.
在EGFR突变的PPA中,在TCGA和免疫组织化学分析中,加列-3的表达显著更高.

结论:

与WT PPA相比,EGFR突变的PPA的预后不太好.
高高的加勒-3表达是EGFR突变的PPA的一个特征.
这些发现强调了在LUAD治疗策略中进行亚型特定分析的重要性.

关键词:

在 Anoikisikis 中.盖莱克-3 是一种皮囊主导的肺腺癌.

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