膜的过早破裂和阴道微生物组的变化 - 益生菌
Kamila Gorczyca1, Małgorzata M Kozioł2, Żaneta Kimber-Trojnar1
1Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Jaczewskiego 8 Street, 20-090 Lublin, Poland.
Reproductive biology
|May 28, 2024
概括
阴道微生物失生症与子宫膜过早破裂 (PPROM) 有关,增加了母亲和新生儿的风险. 益生菌可以帮助预防异常的阴道菌群,并降低孕妇感染的风险.
科学领域:
- 产科和妇科 产科和妇科
- 微生物学 微生物学
- 新生儿科学 新生儿科学
背景情况:
- 过早分娩影响全球1500万,其中30%归因于子膜过早破裂 (PPROM).
- 影响早产的因素包括遗传,荷尔蒙,免疫和社会经济条件.
- 新出现的证据凸显了阴道微生物组在妊娠结果和早产风险方面的重要作用.
研究的目的:
- 审查PPROM中关于阴道微生物组成的研究.
- 评估阴道微生物群在与PPROM相关的早产中的作用.
- 评估益生菌在预防早产方面的潜力.
主要方法:
- 在PPROM中调查阴道微生物群的研究的系统文献综述.
- 关于阴道失调和早产之间的联系的研究分析.
- 对益生菌干预的临床试验和观察性研究的评估.
主要成果:
- 阴道微生物失生症是PPROM病例中常见的发现.
- 失生症与早产,孕产妇感染和新生儿发病/死亡的风险增加有关.
- 益生菌在预防病理性阴道菌群和降低感染风险方面显示出潜力.
结论:
- 阴道微生物组的改变在PPROM和随后的早产中起着至关重要的作用.
- 准阴道失生症可能是预防早产的策略.
- 对生物标志物和益生菌疗效进行进一步的研究是必要的,以获得临床应用.
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