肠道菌群通过影响外周和中央炎症通路,影响下大脑下垂体出血的进展
Ming Zhang1, Xiaokui Gan1, Yiming Fang1
1Department of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, Jiangsu, China.
Brain research
|May 28, 2024
概括
用抗生素改变肠道微生物组显著保护大鼠免受亚结膜下出血 (SAH) 的脑损伤. 这种肠道微生物组调节影响了肠道和内炎症,表明肠道细菌和SAH结果之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 副arachnoid出血 (SAH) 导致严重的神经障碍,没有有效的早期脑损伤 (EBI) 治疗.
- 肠道微生物组 (GM) 影响系统免疫力,并可能影响大脑疾病,但其在SAH结果中的作用尚不清楚.
研究的目的:
- 调查调节肠道微生物组是否会影响SAH后脑损伤的严重程度.
- 探索肠道微生物组成和SAH后的神经炎症之间的关系.
主要方法:
- 通过使用含有抗生素的水两周,改变了老鼠的肠道微生物群.
- 在对照和改变微生物群的小鼠组中,SAH是通过动脉穿刺诱导的.
- 分析了肠道微生物组的组成,肠道和内炎症以及神经炎症因素.
主要成果:
- 肠道微生物组的抗生素诱导的改变显著地保护了SAH诱导的大脑损伤.
- 改变的转基因导致SAH后肠道和内炎症增加.
- 观察到炎症性细胞因子的变化,包括莫辛 (MSN).
结论:
- 肠道微生物组在大脑对脑下关节出血的反应中发挥着重要作用.
- 调节肠道微生物组可能是缓解SAH相关脑损伤的治疗策略.
- 对将转基因和SAH联系在一起的机制进行进一步的研究是有必要的.
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