控制释放的维生素A棕酸盐从交叉链接的环氧素有机框架干眼疾病治疗
Xinyue Ye1, Falan Li1, Mingwei Li1
1Anhui University of Chinese Medicine, Hefei 230012, China; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co., Nantong 226133, China.
International journal of pharmaceutics
|May 28, 2024
概括
新型交叉连接的循环素有机框架 (COFs) 有效地在眼滴中提供维生素A棕酸盐 (VAP). 这种新的COF载体可以延长VAP停留时间,加快干眼疾病的恢复,并具有出色的眼部安全性.
科学领域:
- 材料科学 材料科学 材料科学
- 眼科医生 眼科 眼科
- 药物运输 药物运输 药物运输
背景情况:
- 控制释放眼滴可以改善患者的服从性和减少刺激.
- 开发这些系统的一个重大限制是缺乏合适的眼科药物载体.
- 维生素A棕酸盐 (VAP) 对眼皮表面健康至关重要.
研究的目的:
- 合成和表征一种新型的交叉链接的循环素有机框架 (COF) 作为眼科应用的药物载体.
- 制定和评估含有VAP的COF悬浮眼滴,以增强VAP输送和治疗干眼疾病 (DED) 的疗效.
- 评估VAP@COF悬浮液的眼睛安全性和停留时间.
主要方法:
- 通过无溶剂方法合成具有均颗粒大小的立方多孔COF.
- 通过优化辅溶剂,悬浮剂和稳定剂来配制VAP@COF悬浮眼滴.
- 在体外释放药物的研究,ex vivo角膜接触角度测量和体内光追踪.
- 在子DED模型中评估治疗疗效,评估细胞毒性和眼部刺激.
主要成果:
- 合成的COF成功地使用无溶剂方法封装了VAP.
- 在12小时内,VAP@COF悬浮体表现出受控的VAP释放.
- 悬浮剂显著延长了VAP在眼睛表面的停留时间,并加速了子的DED恢复.
- VAP@COF悬浮液对角膜细胞没有细胞毒性,也没有刺激眼睛.
结论:
- 微粒COF作为一种有效和安全的新型载体,用于眼科药物输送.
- VAP@COF悬浮液提供持续释放和长时间的眼部停留时间,有利于DED治疗.
- 这种基于COF的系统代表了干眼疾病的眼科治疗的有希望的进步.
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