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Updated: Jun 3, 2026

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
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Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

Published on: January 19, 2017

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对29个免疫细胞子集的长读测序揭示了与疾病相关的异型

Jun Inamo1,2, Akari Suzuki3, Mahoko Takahashi Ueda1

  • 1Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8510, Japan.

Nature communications
|May 28, 2024
PubMed
概括

长期阅读的测序揭示了新的人类免疫细胞异型,包括与疾病相关的异型. 这项研究增强了对复杂特征和基因组进化中的替代拼接的理解.

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相关概念视频

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...