产前接触酒精及其对成年人奖励处理和物质使用的影响
Klara Mareckova1,2, Radek Marecek3,4, Lenka Andryskova5
1Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic. klara.mareckova@ceitec.muni.cz.
Translational psychiatry
|May 28, 2024
概括
产前酒精暴露,即使在怀孕中期的中度水平,也会影响大脑的奖励处理,并增加年轻成人大麻使用风险. 这些效应持续数十年,并显示出性别特定的大脑反应.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 怀孕期间母亲大量饮酒与神经发育问题有关.
- 低剂量酒精暴露和怀孕期间安全消费水平的影响尚不清楚.
研究的目的:
- 调查产前酒精暴露对年轻成人奖励相关行为和物质使用的长期影响.
- 探索这些效应中的潜在的性别差异.
主要方法:
- 利用了来自欧洲妊娠和童年长度研究 (ELSPAC) 队列的数据.
- 在怀孕中期和怀孕前期评估母亲的饮酒量.
- 测量了年轻成年人的大脑对使用fMRI和通过自我报告的物质使用奖励的反应.
主要成果:
- 怀孕中期中度的酒精暴露,而不是怀孕前,与大脑奖励反处理的改变和两性大麻使用的增加有关.
- 这些影响独立于母亲的教育和抑郁症.
- 大脑对奖励反的反应预测了以后的大麻使用,独立于当前的酒精消费.
- 性差异出现在大脑对奖励结果的反应中,男性在特定区域表现出更高的反应.
结论:
- 产前酒精暴露,即使是适度的,也会对与奖励处理相关的大脑功能产生持久的影响.
- 产前酒精暴露与年轻成人大麻使用风险增加有关.
- 长期影响和性别特异的神经反应凸显了怀孕期间饮酒的风险.
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