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在整个生命周期中,肥胖的神经相关性
Filip Morys1, Christina Tremblay2, Shady Rahayel3,4
1Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, QC, Canada. filip.morys@mcgill.ca.
Communications biology
|May 28, 2024
概括
肥胖与所有年龄段的大脑皮层厚度的减少有关. 这项研究探讨了与一生中肥胖相关的脑部变化,遗传学和神经化学,表明早期的认知转变可能会影响以后的神经退行.
科学领域:
- 神经科学是一个神经科学.
- 肥胖问题研究研究
- 生命周期发展 寿命发展
背景情况:
- 大脑和肥胖之间的关系是双向的,影响过度饮食行为和大脑结构.
- 了解这些跨生命周期的相互作用对于理解肥胖对大脑健康的影响至关重要.
- 已知慢性肥胖会导致大脑缩和功能变化.
研究的目的:
- 调查不同年龄段的肥胖和皮质形态测量之间的相互作用:儿童,年轻人,成年人和老年人.
- 探索与大脑肥胖关系相关的遗传,神经化学和认知因素.
- 阐明与肥胖相关的大脑结构中的年龄相关模式.
主要方法:
- 对皮层厚度和形态测量与不同年龄组肥胖相关的分析.
- 研究遗传相关物,包括炎症和线粒体基因表达.
- 评估与肥胖相关的神经化学变化和认知功能.
主要成果:
- 肥胖与所有研究年龄组的前时区域皮质厚度降低有关.
- 在其他大脑区域观察到皮质形态的年龄相关变化.
- 在成人和老年人中,肥胖与神经化学变化以及炎症/线粒体基因表达的变化相关. 在儿童和老年人中,肥胖影响了与情绪和注意力有关的大脑区域.
结论:
- 肥胖与广泛的皮质稀薄有关,特别是在前部区域,具有特定于年龄的模式.
- 神经化学和遗传因素,包括炎症和线粒体功能,在与肥胖有关的脑部变化中起作用,特别是在老年人中.
- 这些发现表明,青春期早期的认知变化可能会引发肥胖,可能会通过炎症和线粒体路径导致生命后期的神经退行.
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