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结核菌在缺氧下产生D-胺,以限制小鼠的CD8+ T细胞依赖免疫力

Hongyu Cheng1,2, Zhe Ji1,2, Yang Wang2

  • 1Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, P. R. China.

Nature microbiology
|May 28, 2024
PubMed
概括

结核菌 (Mtb) 在缺氧下产生D-,以逃避免疫反应. 这种代谢物抑制CD8+T细胞的干扰素- (IFN-γ) 生产,削弱了适应性抗结核免疫力.

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