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Updated: Jun 25, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

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通过转化生长因子-β1激活核因子-κB驱动了神经母细胞瘤中瘤微环境介导的耐药性

Kévin Louault1, Laurence Blavier1, Men-Hua Lee1

  • 1Cancer and Blood Diseases Institute, Department of Pediatrics, Children's Hospital Los Angeles and the University of Southern California, Los Angeles, CA, 90027, USA.

British journal of cancer
|May 28, 2024
PubMed
概括

在瘤微环境 (TME) 中转化生长因子β1 (TGF-β1) 通过激活TAK1/NF-κB/SMAD2通路来增强神经母细胞瘤的耐药性. 抑制这种途径会逆转抵抗,提供一个新的治疗点.

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