与代谢功能障碍相关的脂肪肝病和大量饮酒增加死亡率:一项全国性研究
So Hyun Cho1, Seohyun Kim2, Rosa Oh1
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-Ro, Gangnam-Gu, Seoul, 06351, Republic of Korea.
Hepatology international
|May 28, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与大量饮酒相结合,显著增加死亡风险. 这种组合协同增加了与肝脏有关的死亡,突出了酒精对MAFLD预后的关键影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 内部医学 内部医学
背景情况:
- 过度饮酒对代谢功能障碍相关的脂肪肝疾病 (MAFLD) 预后的影响尚不清楚.
- 调查亚洲人被诊断患有MAFLD的不同饮酒水平相关的死亡风险.
研究的目的:
- 检查MAFLD患者的酒精消费模式和死亡率之间的关系.
- 确定与MAFLD和酒精摄入有关的全因和因特定死亡风险.
主要方法:
- 一项全国性的回顾性研究分析了996,508名40-79岁的成年人进行健康检查 (2009-2012).
- 参与者按酒精消费 (非酒精,中度,重度) 和MAFLD状态 (按脂肪肝指数≥30定义) 分层.
- 考克斯的比例危险模型评估了饮酒,MAFLD和死亡结果之间的关联.
主要成果:
- MAFLD与所有原因,肝脏相关和癌症相关的死亡率显著增加有关.
- 患有MAFLD和大量饮酒的个人表现出与肝脏相关的死亡风险最高 (aHR,9.8;95% CI,8.20-12.29).
- 沉重的酒精消费独立地增加了肝脏和癌症相关的死亡风险,无论MAFLD是否存在.
结论:
- 无论是MAFLD还是重度饮酒,都会独立地提高所有原因,肝脏和癌症相关的死亡率.
- 重度饮酒和MAFLD之间存在协同作用,显著放大与肝脏相关的死亡风险.
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