针对儿科功能性便秘的不同益生菌产品加上药的有效性和可接受性:随机对照试验的网络元分析
Wei-Chieh Yang1, Bing-Syuan Zeng2, Chih-Sung Liang3,4
1Department of Pediatrics, Ping An Medical Clinic, Tainan, Taiwan.
European journal of pediatrics
|May 28, 2024
概括
这项网络元分析发现,大多数益生菌补充剂显著改善功能性便秘儿童的肠道运动频率. 蛋白质素与药结合显示出最大的疗效,而Lactobacillus casei rhamnosus Lcr35作为单次干预有效.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 儿科功能性便秘在全球普遍存在,影响0.7-29.6%的儿童.
- 药物治疗儿科便秘的疗效有限 (60%的成功率).
- 关于治疗儿科便秘的益生菌补充剂的现有研究表明,由于使用的不同菌株,结果各不相同.
研究的目的:
- 为了比较各种益生菌补充剂对儿科功能性便秘的疗效和可接受性.
- 为治疗这种疾病提供基于证据的益生菌使用建议.
主要方法:
- 进行了基于频率模型的网络元分析 (NMA).
- 包括9项随机对照试验 (RCT),涉及710名儿童 (平均年龄为5.5岁).
- 主要结局:肠道排便/便频率发生变化;次要结局:因任何原因停止治疗.
主要成果:
- 大多数益生菌产品,单独或与药一起,与安慰剂相比,显著改善了肠道排便频率.
- 蛋白质素加上药显示出最大的改善 (SMD=1.87).
- 乳杆菌casei rhamnosus Lcr35是唯一一个表现出显著有效性的益生菌干预措施 (SMD=1.37).
- 在益生菌组和安慰剂组之间没有观察到便失禁或脱学率的显著差异.
结论:
- 这些发现支持使用先进的益生菌和药组合治疗儿科功能性便秘.
- 乳杆菌casei rhamnosus Lcr35是一种可行的单一益生菌选择.
- 进一步的研究可能会探索最佳的益生菌配方和组合.
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