在爱尔兰癌症中心扩大全身抗癌疗法接入计划的影响
Timothy K Cronin1, Cian Ronayne2, Niamh O'Donovan3
1School of Medicine and Health, University College Cork, Cork, Ireland. 114349821@umail.ucc.ie.
Irish journal of medical science
|May 28, 2024
概括
扩展访问计划 (EAP) 越来越多地用于新型癌症疗法,近年来呈现出越来越大的趋势. 建立国家注册和现实世界数据库可以改善平等的EAP获益的获取和评估.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 扩展获取计划 (EAP) 为未满足需求的患者提供至关重要的研究癌症治疗机会.
- 目前关于EAPs实际影响和标准化实施的数据有限.
- 缺乏标准化的国家流程阻碍了EAP的一致利用.
研究的目的:
- 评估癌症中心内的扩展访问计划 (EAP) 的流行率和影响.
- 分析十年来癌症患者使用EAP的趋势.
- 评估通过EAPs治疗的药物类型和癌症症状.
主要方法:
- 从2011年至2021年,对通过EAPs治疗的成人癌症患者进行回顾性数据收集.
- 包括来自科克三个大学医院的数据.
- 描述性统计分析以确定EAP对癌症护理提供的影响.
主要成果:
- 193名患者通过EAPs获得了50种癌症指示的33种不同的药物.
- 观察到EAP使用的显著上升趋势,有189个程序被访问.
- 向疗法和免疫检查点抑制剂是使用的主要药物类别.
- 在不同年龄组中,EAP药物治疗了广泛的固体和液体瘤.
结论:
- 扩展获取计划 (EAP) 在全国范围内获得新型癌症疗法方面发挥着越来越重要的作用.
- 一个新成立的国家注册表促进了公平的EAP访问.
- 应强制采集现实世界的数据以获得EAP批准,以加强益处和毒性评估.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Survival Analysis
343
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
343
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


