塞维米林和不同度的阿拉伯对状唾液腺功能在甲基酸诱导的异口症的影响:一项比较研究
1Oral Biology Department, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Gamasa, Egypt. Mahmoud.abouelfotouh@deltauniv.edu.eg.
BMC oral health
|May 28, 2024
概括
阿拉伯 (GA) 通过改善老鼠的腺健康,在治疗口腔干燥 (xerostomia) 方面表现有前途. 这种天然口香糖可能为治疗唾液腺功能障碍而提供一种有益的替代品,而不是塞维梅林 (CVM).
科学领域:
- 药理学 药理学是指药理学的学科.
- 历史学 历史学 历史学
- 生物化学 生化学
背景情况:
- 已知甲托雷克萨特 (MTX) 诱导异口症,导致唾液腺功能障碍.
- 塞维梅林 (CVM) 是一种常用于治疗异口症的药物.
- 阿拉伯 (GA) 是一种天然的多糖,具有潜在的治疗性质.
研究的目的:
- 为了评估阿拉伯糖 (GA) 在缓解甲基引发的异口症方面的疗效.
- 为了比较GA与塞维梅林 (CVM) 对腺组织学和细胞增殖/细胞亡的影响.
- 为了研究不同度的GA对腺的影响.
主要方法:
- 给大鼠注射甲状腺素 (MTX) 诱导异口症.
- 实验组接受了塞维梅林 (CVM) 或口服不同度的阿拉伯 (GA).
- 用血素和欧 (H&E) 染色,以及针对caspase-3和Ki67.7的免疫组织化学染色来分析腺.
主要成果:
- 甲三甲酸显著增加酶-3 (亡标记物) 和降低Ki67 (增殖标记物) 在腺.
- 与仅使用MTX的组相比,CVM和GA治疗都调节了caspase-3和Ki67水平.
- 高度的GA (3毫升/公斤) 显示出更有利的趋势恢复正常的组织学和细胞标志物.
结论:
- 阿拉伯 (GA) 在MTX诱导的异口症的小鼠模型中显示出对腺的保护性和潜在的修复性作用.
- GA可能代表一种可行的替代或辅助疗法,用于管理与异口症相关的唾液腺功能障碍.
- 需要进一步的研究来阐明GA作用的精确机制及其临床适用性.
相关概念视频
Direct-Acting Cholinergic Agonists: Therapeutic Uses
731
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
731
Salivary Glands and Saliva
646
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
646
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
229
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
229


