血清骨质保护素及其基因多态性在Takayasu动脉炎患者:一个双中心的横截面研究
Camila da Silva Cendon Duran1, Valéria de Falco Caparbo1, Mittermayer Barreto Santiago2
1Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Advances in rheumatology (London, England)
|May 28, 2024
概括
骨质保护素 (OPG) 没有在塔卡亚苏研究中成为心血管疾病 (CVD) 风险的可靠生物标志物.
科学领域:
- 风湿病学和免疫学
- 心血管医学 心血管医学
- 生物标志物发现发现
背景情况:
- 塔卡亚苏动脉炎 (TAK) 患者面临代谢综合征和心血管疾病 (CVD) 的风险增加.
- 目前缺乏用于评估TAK患者心血管疾病风险的验证生物标志物.
- 骨质保护素 (OPG) 以前与动脉样硬化和心血管疾病的不良预后有关.
研究的目的:
- 研究血清OPG水平和OPG单核酸多态 (SNP) 作为TAK患者心血管疾病风险的潜在生物标志物.
- 为了比较TAK患者和健康对照之间的OPG参数.
- 将OPG水平和SNP与与心血管疾病风险相关的临床数据相关联.
主要方法:
- 一个双中心的横截面研究,将101名TAK患者与93名健康对照进行比较.
- 测量血清OPG水平的方法.
- 四个OPGSNP的基因型定型:1181G>C (rs2073618),245A>C (rs3134069),163T>C (rs3102735) 和209C>T (rs3134070). 这四个OPGSNP的基因型定型包括:1181G>C (rs2073618),245A>C (rs3134069),163T>C (rs3102735) 和209C>T (rs3134070).
- 对OPG参数与临床数据和心血管疾病风险因素的关联分析.
主要成果:
- 在TAK患者和对照人群之间,血清OPG水平没有显著差异 (P=0.059).
- 四个研究的OPGSNP的频率在两组之间是可比的.
- 在TAK患者中,血清OPG水平和OPGSNP与心血管疾病参数无关,而在没有失脂症的患者中,OPG趋势较高.
结论:
- 血清OPG水平和OPGSNP似乎不是高山氏动脉炎中心血管疾病风险的可靠生物标志物.
- 在研究的TAK患者队列中,OPG参数和心血管疾病风险因素之间没有发现显著的关联.
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