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法国多中心分子分析平台和个性化医学试验MOST,MOST Plus和MEGAMOST

Loic Verlingue¹, Marine Desevre², Marie Polito²

¹Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France. loic.verlingue@lyon.unicancer.fr.

Acta oncologica (Stockholm, Sweden)

|May 29, 2024

概括

法国学术分子分析平台如PROFILER和个性化医学试验MOST,MOST Plus和MEGAMOST都是详细的. 这些举措对癌症研究和治疗有影响,正在不断招募患者.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
临床试验临床试验

背景情况:

法国学术分子分析平台的描述.
这里介绍了PROFILER,MOST,MOST Plus和MEGAMOST的举措.

研究的目的:

详细介绍法国多中心分子分析平台的结构和范围.
介绍个性化医学试验的设计和进展情况.

主要方法:

概述PROFILER平台的情况.
描述了MOST,MOST Plus和MEGAMOST试验,包括14个队列.
在试验设计中包括向药物和免疫疗法.

主要成果:

在过去的10年里,PROFILER已经招募了5991名患者.
自2014年以来,MOST和MOST Plus已经招募了875名患者.
自2020年以来,MEGAMOST已经招募了172名患者,并正在为所有试验招募患者.

结论:

这些平台和试验具有重要的当地,国家和国际影响.
对索拉费尼布和奥拉帕里布队列结果的审查提供了对治疗疗效的见解.
持续的患者招募突显了这些举措的持续重要性和扩展.

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