塔利多米德是一种安慰剂催眠药吗?
1College of Humanities and Sciences, University of Montana, Missoula, MT, USA.
概括
沙利多米德是一种镇静剂,在100mg的睡眠中被发现是无效的,相当于安慰剂. 尽管如此,孕妇被处方这种剂量,冒着无益的产物效应的风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 甲状腺学 甲状腺学
- 临床试验 临床试验
背景情况:
- 沙利多米德是一种镇静催眠药,尽管它会导致严重的出生缺陷,如虫病,但却被广泛处方.
- 即使在临床上使用它,对其安全性和有效性的担忧仍然存在.
研究的目的:
- 为了评估thalidomide作为睡眠辅助剂的有效性.
- 为了比较不同剂量的thalidomide与安慰剂.
主要方法:
- 1960年路易斯·拉萨尼亚 (Louis Lasagna) 进行的一项临床试验测试了thalidomide与安慰剂的对比.
- 服用了100mg和200mg的thalidomide剂量,并对诱导睡眠的影响进行了比较.
主要成果:
- 与安慰剂相比,thalidomide的100mg剂量在诱导睡眠方面没有显著差异.
- 发现200mg剂量在产生睡眠方面优于安慰剂和100mg剂量.
结论:
- thalidomide的100mg剂量作为睡眠辅助剂是无效的,与安慰剂相比没有任何好处.
- 孕妇处方100毫克的thalidomide暴露于无治疗益处的致病风险.
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