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相关概念视频

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
2.5K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

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In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
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"硬质皮肤病"和"类似硬质皮肤病"的毛细膜显微镜模式-差异和相似之处

Sevdalina Nikolova Lambova1,2, Ulf Müller-Ladner3,4

  • 1Department of Propaedeutics of Internal Diseases "Prof Dr Anton Mitov", Faculty of Medicine, Medical University of Plovdiv, Bulgaria.

Current rheumatology reviews
|May 29, 2024
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概括

毛细管镜检查揭示了系统性硬化症 (SSc) 和其他类风湿性疾病中明显的微血管模式. 虽然存在一些重叠,但皮肤肌炎,狼和类风湿性关节炎中的特定"类似于硬质皮肤"的特征有助于区分.

关键词:
毛细毛囊显微镜是指毛细毛囊显微镜.在UCTD.结合组织疾病 结合组织疾病微血管损伤是什么意思系统性硬化症 系统性硬化症类似于硬化性皮肤

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科学领域:

  • 类风湿病学 类风湿病学
  • 皮肤病学 皮肤病学
  • 血管生物学 血管生物学

背景情况:

  • "硬质皮肤病"的毛细膜学图案是系统性硬化症 (SSc) 的标志性特征,在90%以上的患者中存在.
  • 在其他类风湿性疾病中也观察到类似的"类似于硬质皮肤"的模式,如皮肤肌炎 (DM),全身性红斑狼 (SLE) 和不分化的结缔组织疾病 (UCTD).
  • 微血管变化通过"早期"",活跃"和"晚期"阶段的进展,受疾病持续时间和其他因素的影响.

研究的目的:

  • 为了确定SSc中的"硬化皮肤"模式和其他类风湿性疾病中的"硬化皮肤样式"模式之间的区别特征.
  • 分析毛细管镜像以检测不同的形态特征.
  • 评估毛细管学在区分SSc与其他连接组织疾病方面的有用性.

主要方法:

  • 对684张来自SSc,DM,SLE,类风湿性关节炎 (RA) 和UCTD患者的毛细管学图像进行了回顾性横截分析.
  • 毛细血管直径,密度和毛细血管间距离的定量评估.
  • 根据既定的标准,将图像分为"早期"",活跃"",晚期"或"其他"阶段.

主要成果:

  • 在RA,SLE和UCTD中发现了"早期"的微血管病变,但没有DM. 在所有非SSc组中都存在"活跃"模式.
  • 在SSc和DM中观察到"晚期"阶段的微血管病变,但在SLE,RA或UCTD中没有.
  • 在RA患者中,注意到了"风湿性新血管性模式"等特定发现.

结论:

  • 虽然"样"模式可以模仿SSc,但存在区分特征.
  • 早期的微血管病变在RA,SLE和UCTD中很常见,而"晚期"阶段更适用于SSc和DM.
  • 这些形态差异表明,在类风湿性疾病中,病原和微血管损伤存在差异.