补充婴儿配方奶粉多菌株共生和骨质增强了结肠微生物的殖民化,并修改了哺乳小猪的乳房基因表达
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Updated: Apr 30, 2026

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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
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Laia Ferreres-Serafini1, Susana Mª Martín-Orúe1, Meritxell Sadurní1
1Animal Nutrition and Welfare Service, Department of Animal and Food Science, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. gd.animal.aliments@uab.cat.
Food & function
|May 29, 2024
概括
用协生菌和骨质素补充小猪奶配方改善了肠道健康和免疫反应. 组合的CON饮食增强了结肠殖民和调节免疫基因表达.
科学领域:
- 动物营养 动物营养
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 新生儿腹在小猪生产中是一个重大挑战.
- 肠道微生物群和宿主免疫反应对于小猪的健康和发育至关重要.
- 饮食干预可以调节年轻动物的肠道健康和免疫功能.
研究的目的:
- 评估单独或组合使用的协生菌和骨质松素对小猪生长,临床症状和肠道健康的影响.
- 调查这些补充剂对结肠微生物群,发酵活性和内基因表达的影响.
- 探索牛奶配方中的协同生物和骨质素之间的潜在协同效应.
主要方法:
- 96只断奶小猪被养四种饮食之一:控制 (CTR),CTR + 协生菌 (SYN),CTR + 骨质素 (OPN) 或CTR + SYN + OPN (CON).
- 在15天内记录了生长表现,临床症状和料摄入量.
- 血液,消化器和肠道组织的样本被分析为血清TNF-α,短链脂肪酸 (SCFA),氨,结肠微生物群 (16S rRNA测序),组织形态学和状基因表达.
主要成果:
- 骨质疏松素补充剂增加了料摄入量,而共生菌减少了腹持续时间.
- 康尼饮食改善了对抗生素细菌的控制,增加了结肠SCFA,减少了氨,并减少了内皮淋巴细胞.
- 协生菌对肠道成熟和营养物质运输的基因进行上调,同时对炎症和病原体反应基因进行下调. 奥斯托邦丁可以提高消化基因 (GCG) 的调节.
结论:
- 综合合成生物和骨质补充剂 (CON饮食) 显示出协同效应,改善了小猪的结肠殖民和免疫反应调节.
- 饮食干预可以积极影响肠道微生物群组成和宿主-病原体相互作用.
- 对微生物群与宿主通信机制的进一步研究是有必要的.
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