用营养丰富的蛋增强内皮功能:一项针对急性冠状动脉综合征康复患者的随机研究
Ana Marija Masle1,2,3, Aleksandar Kibel3,4,5,6, Ivana Jukić3,4
1Department of Rheumatology, Clinical Immunology and Allergology, University Hospital Osijek, Osijek, Croatia.
Clinical interventions in aging
|May 29, 2024
概括
含有n-3多不和脂肪酸 (n-3PUFA),维生素E和的丰富卵子改善了后急性冠状动脉综合征 (ACS) 患者的微血管功能. 这种饮食干预对抗氧化酶活性产生了积极的影响,但没有增加氧化应激标志物.
科学领域:
- 心血管医学 心血管医学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 患有急性冠状动脉综合征 (ACS) 的患者有微血管功能障碍的风险.
- 饮食干预可以提供一种新的方法来改善ACS患者的心血管健康.
研究的目的:
- 研究食用富含n-3多不和脂肪酸 (n-3PUFA),黄蛋白,维生素E和的食用蛋对ACS患者微血管功能,氧化应激和炎症调解物的影响.
主要方法:
- 一个前性,随机的,双盲临床试验,涉及ACS患者.
- 参与者每天在3周内食用丰富的 (Nutri4) 或对照蛋.
- 评估生物化学参数,抗氧化酶活性,氧化应激标志物和微血管血流反应.
主要成果:
- Nutri4蛋的消费显著降低了LDL胆固醇,并增加了血清维生素E和水平.
- 微血管反应性,通过闭塞后反应性高血压 (PORH) 和乙胆诱导扩张 (ACh ID) 测量,显示明显改善.
- 丰富的蛋增强了谷氨酸过氧化酶 (GPx) 和超氧化物脱氧化酶 (SOD) 的活性,而没有改变硫酸反应物质 (TBARS) 或铁还原能力 (FRAP) 的值.
结论:
- 摄入Nutri4蛋对患有ACS的个体的微血管功能有积极的影响.
- 这种饮食干预表明了有利的安全性,对氧化应激标志物没有不良影响.
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