细菌天然产品通过生物催化剂的晚期多样化
Jelena Lazic1, Vuk Filipovic1, Lena Pantelic1
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Frontiers in bioengineering and biotechnology
|May 29, 2024
概括
生物催化剂使细菌天然产品 (BNPs) 的晚期多样化成为可能,为药物发现提供了一种绿色化学方法. 本综述详细介绍了来自12个BNP的73种衍生物和16种降解产品,突出了新药开发的潜力.
科学领域:
- 生物化学和药物化学 医学化学
- 绿色化学和生物催化剂
- 药物发现和开发 药物发现和开发
背景情况:
- 细菌天然产品 (BNPs) 对新药的潜在客户至关重要.
- 生物催化剂为BNP多样化提供了化学合成的替代方案.
- 对于BNP生物合成途径的基因组数据仍未得到充分探索.
研究的目的:
- 系统地审查BNPs的生物催化生物转化.
- 探索生物活性支架的后期多样化策略.
- 确定产生新候选药物的潜力.
主要方法:
- 在21个BNP中对生物转化进行系统审查.
- 根据生物活性对BNPs的分类 (抗菌,抗真菌,抗癌,免疫抑制,定数感应调节).
- 生物催化反应的分析,包括衍生和降解.
主要成果:
- 从12个BNPs中总结了73种衍生物和16种降解子衍生物.
- 观察到万科米辛 (28次反应) 和拉帕米辛 (18次反应) 的广泛生物催化.
- 确定了氧化还原酶,转移酶,脂酶,异构酶和氧化酶作为常见的生物催化剂.
结论:
- 生物催化是一种可行的绿色化学方法,用于BNPs的晚期多样化.
- 这种方法促进了生物活性支架的结构优化.
- 突出了开发新生物分子和候选药物的潜力.
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