变化大脑网络连接和主观经验诱导的迷幻药:一个范围审查
Zijia Yu1, Lisa Burback1, Olga Winkler1
1Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
Frontiers in psychiatry
|May 29, 2024
概括
像psilocybin和LSD这样的迷幻药物改变了大脑的连接,影响了主观经验. 本综述将这些神经变化与心理健康障碍的潜在治疗效应联系起来.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
背景情况:
- 迷幻药对心理健康障碍有治疗潜力.
- 迷幻药物的主观影响与其有效性有关.
- 大脑功能连接的变化与迷幻体验有关.
研究的目的:
- 审查迷幻药对大脑功能连接的影响.
- 探索主观体验和神经生理学变化之间的关系由迷幻药物诱导.
主要方法:
- 从MEDLINE,Embase,APA PsycInfo和Scopus (开始至2023年6月) 的24篇文章进行范围审查.
- 专注于阿雅华斯卡, псилоцибин,LSD 和 MDMA.
- 分析了对健康个体的研究,量化主观效应和神经成像数据.
主要成果:
- 迷幻药物引起了显著的意识变化,情绪升高和神秘体验.
- 一致的发现是,默认模式网络连接性下降,物质之间感官/甲状腺皮层连接性增加.
- 观察到神经生理变化和主观经验之间的相关性,表明大脑网络的基础.
结论:
- 迷幻药调节大脑的功能连接,可能是其神经心理影响的基础.
- 研究结果表明,迷幻的主观效应存在神经机制.
- 需要进一步的临床证据来确认治疗潜力.
相关概念视频
Hallucinogens and Psychedelics
163
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
163
Altered States of Awareness
179
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
179
CNS Stimulants: Psychedelic Agents
147
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
147
An Overview of Psychoactive Drugs
214
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
214
Neuroplasticity
328
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
328
Dissociative Disorders
65
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
65


