扩展ABCC工具用于骨关节炎:开发和内容验证
V H J Debie1, T A E J Boymans2, R P G Ottenheijm1
1Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands.
Osteoarthritis and cartilage open
|May 29, 2024
概括
骨关节炎患者希望以个人为中心的护理,重点关注身体,情绪和社会因素. 开发了一个新的慢性疾病负担评估 (ABCC) 工具模块,以提高OA护理质量和共享决策.
科学领域:
- 风湿病学和肌肉骨健康
- 医疗保健服务研究 医疗服务研究
- 患者报告的结果衡量结果.
背景情况:
- 目前的骨关节炎 (OA) 管理往往依赖于一个阶段性护理方法,只关注身体症状.
- 骨关节炎患者主张采用更全面,以人为中心的护理模式,整合身体,情感和社会福祉.
- 现有的评估工具可能无法从患者的角度完全捕捉OA的多方面的负担.
研究的目的:
- 开发一种针对慢性病症负担评估 (ABCC) 工具的新型,特定条件的模块,适用于骨关节炎 (OA) 护理.
- 通过整合OA的身体,情感和社会方面来增强ABCC工具,超越纯粹基于症状的评估.
- 通过更全面的评估,提高经验丰富的OA护理质量,促进共享决策.
主要方法:
- 采用了涉及OA患者和医疗保健专业人员的三角代过程.
- 文献搜索和专家小组商为该模块的开发提供了信息.
- 用COSMIN方法评估内容有效性,包括患者反和医疗保健专业人员项目内容有效性指数 (I-CVI) 的计算.
主要成果:
- 开发的OA模块包括针对疼痛,运动恐惧症和关节硬性的具体问题.
- 94%的关节炎患者认为这些问题对他们的病情很重要.
- 医疗保健专业人员的I-CVI分数在0.75 (关节硬) 到1.0 (疼痛,动态恐惧症) 之间,表明内容有效性良好.
结论:
- 为ABCC工具成功开发了一种新的,特定条件的OA模块.
- 本模块通过测量OA特定投诉来补充现有的通用问题.
- 增强的ABCC工具旨在更全面,适用于更广泛的OA患者群体.
相关概念视频
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Growth of Cartilage and Bone Tissue
3.2K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.2K
Bone Formation by Endochondral Ossification
4.4K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.4K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Improving Translational Accuracy
10.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
10.1K
Changes in the Appendicular Skeleton with Age
2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K


