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对自身免疫性甲状腺功能低下症患者的抗Tg抗体的影响:一项随机对照试验
Mina AkbariRad1, Zahra Mazloum Khorasani2, Behnam Beizae3
1Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Caspian journal of internal medicine
|May 29, 2024
概括
口服补充剂在患有自身免疫性甲状腺功能低下症的患者中显著降低了抗thyroglobulin (抗Tg) 抗体. 还改善了甲状腺激素水平,提供了超越标准甲 (LT4) 治疗的潜在治疗益处.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 自免疫性甲状腺功能低下症的特征是抗甲状腺蛋白 (anti-Tg) 抗体升高.
- 用levothyroxine (LT4) 进行甲状腺激素替代疗法是标准的护理.
- 补充剂在治疗自身免疫性甲状腺功能低下症中的作用需要进一步研究.
研究的目的:
- 为了评估口服摄入量降低抗Tg抗体水平的疗效.
- 评估对甲状腺刺激激素 (TSH) 和自免疫性甲状腺功能低下症患者的自由甲状腺素 (T4) 水平的影响.
主要方法:
- 进行了一项双盲随机对照试验,其中144名患者被诊断患有自身免疫性甲状腺功能低下症.
- 参与者被分配给接受口服的LT4或安慰剂的LT4.
- 在干预前和干预后3个月进行了抗Tg抗体,抗TPO抗体,TSH和自由T4的测量.
主要成果:
- 干预组 (LT4 + ) 与安慰剂组相比,在统计学上显著地减少了抗Tg抗体 (P = 0.03).
- 在组中,TSH水平显著下降 (p < 0.05),自由T4水平显著增加 (p < 0.05).
结论:
- 口服补充剂有效降低自身免疫性甲状腺功能低下症患者的抗Tg抗体.
- 摄入通过增加自由T4和降低TSH水平,对甲状腺功能产生积极影响.
- 可以作为一种有效的辅助疗法,用于自身免疫性甲状腺功能低下症.
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