患有腹腔疾病的儿童和成人甲状腺疾病:一个横截面研究
Ramin Niknam1, Heydar Baseri1, Laleh Mahmoudi2
1Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Caspian journal of internal medicine
|May 29, 2024
概括
患有乳病 (CD) 的成年人患甲状腺疾病 (TD) 的风险更高. 父母的家族婚姻也增加了CD患者的TD概率,与血清水平或组织学损伤不同.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 病 (CD) 是一种自身免疫性疾病,具有潜在的肠外表现.
- 甲状腺疾病 (TD) 是CD患者常见的并发症.
- 关于影响CD患者TD发展的因素的数据有限.
研究的目的:
- 研究各种因素与成人和被诊断患有乳病的儿童患甲状腺疾病 (TD) 的概率之间的关联.
- 在CD患者中确定TD的特定风险因素.
主要方法:
- 分析了538名乳病患者的队列.
- 通过十二指腺组织病理学 (Marsh型2或更高) 和阳性抗转谷氨酶抗体 (anti-tTG) 水平 (≥18 IU/ml) 确认了CD诊断.
- 使用后勤回归分析来评估甲状腺疾病 (TD) 发展的可能性.
主要成果:
- 总体而言,CD患者中有10.6%患有TD,甲状腺功能低下更为普遍 (9.1%).
- 与儿童相比,成年CD患者患TD的概率明显高于儿童 (OR1.9).
- 父母的家庭婚姻与TD (OR 2.3) 的几率明显更高,而胃肠道症状,抗tTG水平和马什分类严重程度并没有显示出显著的关联.
结论:
- 晚年和父母血缘关系被确定为患有乳病 (CD) 患者发生甲状腺疾病 (TD) 的重要危险因素.
- 组织学损伤的严重程度,抗tTG水平和胃肠道症状与该人群中TD风险增加没有显著关联.
- 进一步的研究可能会阐明这些因素与CD的TD发展联系在一起的潜在机制.
相关概念视频
Other Disorders of Digestive System
787
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
787
Autoimmune Disorders
417
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
417
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Chronic Bowel Disorders: Introduction
442
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
442
Inflammatory Bowel Disease II: Crohn's Disease
217
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
217
Diabetes: Symptoms, Diagnosis, and Complications
524
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
524


