MAFLD:一个理想的框架来了解正常体重个体的疾病表型
Ziyan Pan1, Maryam Al Khatry2, Ming-Lung Yu3,4
1Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia.
Therapeutic advances in endocrinology and metabolism
|May 29, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 影响全球三分之一的人口. 本综述侧重于瘦身MAFLD,探索其机制并将其定义为正常体重个体.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢医学是一种代谢医学.
- 内部医学 内部医学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 影响全球近三分之一的人口,导致严重的肝病和增加的死亡率.
- MAFLD与心脏代谢疾病密切相关,但其在非肥胖个体 (瘦身MAFLD) 中的发生情况尚不清楚.
- 精益MAFLD具有独特的临床特征和进展途径,需要进一步描述.
研究的目的:
- 提供关于瘦肉MAFLD的当前知识的全面审查.
- 提供对正常体重个体的MAFLD定义的视角.
- 阐明底层的生理机制和瘦肉MAFLD的更广泛的代谢背景.
主要方法:
- 文献综述综合了关于MAFLD和瘦身MAFLD的当前研究.
- 分析代谢健康和灵活性在MAFLD发展中的作用.
- 讨论瘦肉MAFLD的临床特征,进展和诊断标准.
主要成果:
- MAFLD是一个重要的全球健康问题,导致肝脏疾病和死亡率.
- 瘦身MAFLD代表了该疾病的一个独特的子集,发生在没有肥胖的人身上.
- 代谢健康和灵活性是关键因素,将代谢不良与瘦身MAFLD联系起来.
结论:
- 瘦身MAFLD需要特别的临床关注和进一步研究其机制.
- 在正常体重的个体中定义MAFLD需要考虑代谢状态.
- 了解代谢灵活性对于对MAFLD管理的综合方法至关重要.
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