怀孕和分娩开始期间血清皮质醇的变化:一项现场横截面研究
Yujuan Chai1, Hairong Wang2, Daiyu Tang3
1Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.
Frontiers in endocrinology
|May 29, 2024
概括
血清皮质醇水平可以帮助诊断受威胁的分娩的分娩开始. 快速的护理点检测有助于孕妇的临床决策.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 孕妇的皮质醇在怀孕和分娩期间增加.
- 诊断的局限性阻碍了对威胁性劳动和实际劳动之间的皮质醇变化的理解.
- 这项研究调查了怀孕晚期和早期分娩时的血清皮质醇动态.
研究的目的:
- 为了评估在怀孕晚期和满期劳动开始期间血清皮质醇的变化.
- 为了确定皮质醇是否可以作为生物标志物来区分分工资与受威胁的劳动.
- 评估治疗点检测对快速皮质醇测量的实用性.
主要方法:
- 这是一项针对6个妊娠阶段的564名参与者的横截面研究.
- 血清皮质醇量测量使用治疗点测试 (POCT).
- 机器学习算法用于根据皮质醇水平和临床变量区分劳动和威胁劳动.
主要成果:
- 皮质醇度从第一季度到第三季度,以及在受威胁的分娩和分娩之间显著增加 (P<0.001).
- 皮质醇水平显示出高的诊断准确性 (86.50%的灵敏度,88.60%的特异性,0.934AUC) 的劳动启动.
- 纳入额外的变量略有提高了特异性,达到89.29%.
结论:
- 血清皮质醇是一种潜在的生物标志物,用于诊断受到威胁的分娩的分娩开始.
- 快速检测血清皮质醇的POCT可以帮助临床决策入院和治疗.
- 皮质醇测试提供了一种有价值的诊断工具,特别是当其他平台无法使用时.
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