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Updated: Jun 25, 2025

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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口服微机器人用于药物输送

An Ren1,2, Jiarui Hu1,2, Changwei Qin1,2

  • 1State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China.

Bioactive materials
|May 29, 2024
PubMed
概括

药物递送微机器人为口腔治疗提供了有前途的解决方案,克服了生物可用性和胃肠道内的向递送方面的挑战. 本文通过推进方式对微机器人进行了分类,讨论了设计,材料和临床翻译前景.

关键词:
生物制剂 生物制剂 生物制剂药物输送是药物输送的过程.胃肠道 胃肠道 胃肠道微型机器人 微型机器人通过口服进行管理.

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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