与衰老相关的NM肌酶表达和收缩性在抗性血管中的降低
Young Soo Han1, Rishiraj Bandi1, Matthew J Fogarty1
1Departments of Physiology and Biomedical Engineering and Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.
Frontiers in physiology
|May 29, 2024
概括
衰老会降低非肌肉 (NM) 髓表达和中腔动脉中的力量,但不会改变LZ+ MYPT1表达或NO介导的血管扩张敏感性.
科学领域:
- 血管生物学 血管生物学
- 衰老的研究研究.
- 顺滑肌肉生理学 顺滑肌肉生理学
背景情况:
- 血管调节涉及肌轻链激酶 (MLCK) 和MLC酸酶.
- 老化血管表现出增加的刚性和降低对氧化 (NO) 介导的血管扩张的敏感性.
- MYPT1异型 (LZ+和LZ-) 通过替代mRNA剪接影响NO敏感性.
研究的目的:
- 调查老化是否会改变LZ+ MYPT1和非肌肉 (NM) 肌肉素表达.
- 确定这些变化对血管活性和NO介导血管扩张的影响.
主要方法:
- 在年轻 (6个月) 和老年 (24个月) 鼠的中腔动脉中评估了MYPT1和NM髓表达.
- 测量力和对内皮依赖和独立放松的敏感性.
- 分析了光滑肌肉细胞缩和中间层厚度.
主要成果:
- 衰老降低了NM髓素的表达和强度.
- 随着年龄的增长,LZ+ MYPT1表达和对血管扩张的敏感性保持不变.
- 在老老鼠中,光滑肌肉细胞缩增加了中间层厚度.
结论:
- 随着年龄的增长,减少的NM髓可能会补偿中间厚度的增加,使血管硬度正常化.
- 衰老不会改变LZ+ MYPT1表达或中枢动脉中NO介导血管扩张的敏感性.
相关概念视频
The Role of Actin and Myosin in Non-muscle Cells
3.5K
Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They are held...
3.5K
Smooth Muscle Contraction
2.8K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
2.8K


