自闭症谱系障碍诊断和先天性细胞巨乳病毒
Megan H Pesch1, Jessica Leung2, Tatiana M Lanzieri2
1Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
那些被诊断为患有先天性细胞大脑病毒 (cCMV) 的儿童,更有可能被诊断为自闭症谱系障碍 (ASD). 在一项大型的医疗补助申请数据分析中观察到这种关联.
科学领域:
- 儿科健康 儿科健康
- 传染性疾病 传染性疾病
- 神经发育障碍 神经发育障碍
背景情况:
- 先天性细胞巨乳病毒 (cCMV) 是新生儿常见的病毒感染.
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 需要进一步调查cCMV和ASD之间的潜在联系.
研究的目的:
- 调查先天性细胞大脑病毒 (cCMV) 与自闭症谱系障碍 (ASD) 在美国儿童的行政诊断之间的关联.
- 分析行政索赔数据以识别患有cCMV和ASD的儿童.
主要方法:
- 一项队列研究利用了2014年至2020年的医疗补助申请数据.
- 诊断代码确定了0至7岁儿童的cCMV (暴露) 和ASD (结果).
- 考克斯比例危险回归模型被用来估计危险比率,调整共变量并按性别,出生结果和中枢神经系统 (CNS) 异常分层.
主要成果:
- 这项研究包括近300万名儿童,1044名儿童患有cCMV,超过74,000名儿童患有ASD.
- 患有cCMV的儿童显示,ASD诊断的可能性增加了2.5倍 (HR:2.5;95%CI:2.0-3.2).
- 根据性别和中枢神经系统异常的存在,cCMV和ASD之间的关联有所不同.
结论:
- 在医疗补助索赔数据中,患有cCMV诊断的儿童患有ASD诊断的可能性明显更高.
- 这些发现表明cCMV和ASD之间存在潜在联系,特别是在症状病例中.
- 建议使用通用cCMV查队列进行进一步的研究,以澄清这些关联.
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