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科伊克斯芽会影响Huh7细胞和高脂肪饮食诱导的肥胖小鼠中的三糖代谢
Mi-Rae Shin1, Min Ju Kim1,2, Jin A Lee1
1Department of Herbology, College of Korean Medicine, Daegu Haany University, Daegu, Republic of Korea.
Journal of medicinal food
|May 29, 2024
概括
科伊克斯 (Coix lacryma-jobi) 芽 (CS) 通过激活脂肪甘油酸脂酶 (ATGL) 和抑制甘油酸合成,减少脂肪积累. 这项研究表明,CS是肥胖管理的有希望的药物.
科学领域:
- 生物化学 生物化学
- 代谢研究研究 代谢研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 脂解,即甘油三 (脂肪) 的分解,对于能量代谢至关重要.
- 脂肪三糖 lipase (ATGL) 是细胞内脂解中的一个关键酶.
- 肥胖是一种复杂的代谢障碍,其特点是过度的脂肪积累.
研究的目的:
- 为了研究Coix lacryma-jobi (Coix) 芽 (CS) 的抗肥胖潜力.
- 阐明CS在调节脂质代谢中的潜在机制.
- 评估CS对脂解和脂质合成途径的影响.
主要方法:
- 在体外研究中使用暴露于自由脂肪酸 (FFAs) 的Huh7细胞.
- 在体内研究中,使用C57BL/6J小鼠食高脂肪饮食.
- 对细胞内甘油三水平,基因表达 (Pparγ,Srebp1c,Pnpla3,ATGL),体重,脂肪组织体重,血清脂质生物标志物和组织组织学的分析.
主要成果:
- CS治疗显著降低了Huh7细胞中的细胞内甘油三水平.
- CS降低了Pparγ和Srebp1cmRNA的表达和突变的Pnpla3mRNA.
- 在小鼠中,CS显著上调ATGL表达,导致体重增加减少, epididymal脂肪组织重量减少,以及改善脂质谱和组织组织学.
结论:
- 科伊克斯 (Coix lacryma-jobi) 芽通过激活ATGL和抑制甘油三合成酶来抑制脂质积累.
- 在体外和体外模型中,CS显示出显著的抗肥胖作用.
- CS作为治疗肥胖的潜在治疗剂具有前景.
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