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在早产和早产之间,母亲下微生物组的差异:MOHEPI研究

Jung Soo Park¹, Eunha Kim^2,3, Sun Jae Kwon⁴

¹Department of Periodontology, Korea University Anam Hospital, Seoul, Republic of Korea.

Journal of periodontal research

|May 29, 2024

概括

孕产妇的牙炎症和口腔微生物组合在早产 (PTB) 和满期出生 (FTB) 组之间有所不同. 在高度炎症的情况下,与FTB母亲相比,PTB母亲的口腔微生物组失生症减少.

科学领域:

口腔微生物学口腔微生物学
孕产妇健康孕产妇健康
产科产科产科产科产科

背景情况:

牙周炎是早产 (PTB) 的潜在危险因素,但确切的机制尚不清楚.
了解口腔微生物组在PTB中的作用对于母婴健康至关重要.

研究的目的:

为了比较经历过PTB的母亲和满期分娩 (FTB) 的母亲之间的口腔微生物组特征.
调查牙周健康和PTB结果之间的关联.

主要方法:

预计将招收60名女性 (30名PTB,30名FTB).
下斑块样本通过metagenomic 16S rDNA测序进行分析.
临床牙周测量和产科数据收集.

主要成果:

牙炎症 (mGI评分) 与PTB显著相关.
在PTB和FTB母亲之间观察到不同的微生物组成,即使炎症很小.
在高炎症组中,与FTB母亲相比,PTB母亲的口腔微生物组失生症减少.

结论:

根据发炎水平,PTB和FTB母亲之间的孕产妇下膜微生物组组成不同.
与FTB母亲相比,PTB母亲的高牙炎症与口腔微生物组失调症的减少有关.

关键词:

这种疾病叫做dysbiosis.这是一种炎症炎症炎症炎症.口腔微生物组是口腔的微生物组.牙周炎是指牙周炎的一种疾病.过早出生过早出生

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