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身体活动,久坐不动的行为,以及功能性胃肠道疾病的风险:一个双样本的门德尔随机化研究

Yan Rui Wu¹, Zong Biao Tan¹, Yi Lu²

¹Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

Journal of digestive diseases

|May 29, 2024

概括

适度至剧烈的体力活动 (MVPA) 和休时间 (LST) 与刺激性肠综合征 (IBS) 风险有因果关系. 增加的MVPA可能会降低IBS风险,而增加的LST可能会增加它,帮助初级预防策略.

科学领域:

胃肠病学胃肠病学
遗传学遗传学是一种遗传学.
公共卫生公共卫生

背景情况:

功能性消化不良 (FD) 和刺激性肠综合征 (IBS) 是常见的功能性胃肠道疾病 (FGID).
了解生活方式因素 (如体力活动和久坐行为) 与FGID之间的因果关系对于制定有效的预防和管理策略至关重要.

研究的目的:

调查身体活动,久坐行为和发展功能性消化不良症 (FD) 和刺激性肠综合征 (IBS) 的风险之间的潜在因果关系.

主要方法:

使用了使用大规模基因组广泛关联研究 (GWAS) 数据的门德尔随机化 (MR) 分析.
利用体力活动和久坐行为的遗传仪器,使用来自FinnGen研究的FD和IBS的总结级GWAS数据.
应用逆方差加权 (IVW) 方法来估计因果关系,并进行灵敏度分析以确保稳定性.

主要成果:

在中度至剧烈的体力活动 (MVPA),休时间 (LST),工作中的久坐行为 (SDW) 或久坐通勤 (SDC) 与FD风险之间没有发现显著的因果关系.
基因预测的MVPA显示了与FD风险 (OR 0.63) 的保护性关联.
MVPA因果关联与IBS风险降低 (OR 0.58),而增加的LST与IBS风险增加 (OR 1.33) 有积极关联.

结论:

中度至强度的体力活动 (MVPA) 和休时间的屏幕时间 (LST) 被确定为与发展IBS的风险相关的因果关系.
这些发现支持身体活动和屏幕时间在IBS初级预防中的作用,为公共卫生干预提供了潜在的目标.

关键词:

门德尔的随机化分析分析.因果关系影响因果关系影响.运动就是炼身体.功能性胃肠道疾病功能性胃肠道疾病一个久坐不动的行为.

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