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达沙替尼和索拉芬尼的增强生物可用性和减少变异性,采用一种新型无形固体分散技术平台

Hans Lennernäs1, Magnus Brisander2, Charlotta Liljebris2

  • 1Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.

Clinical pharmacology in drug development
|May 29, 2024
PubMed
概括

一种新的纳米粒子形态固体分散 (ASD) 技术改善了口服蛋白激酶抑制剂 (PKI) 的吸收,并降低了可变性. 这种配方增强了达沙替尼和索拉费尼布等药物的生物可用性和一致性.

关键词:
吸收 吸收 吸收 吸收无形固体分散的无形固体分散生物可用性 生物可用性生物等价性 生物等价性达萨提尼布 (dasatinib) 是一种药物输送是药物输送的过程.蛋白质激酶抑制剂蛋白质激酶抑制剂索拉芬尼布 (Sorafenib) 是一个铁氨基激酶抑制剂 铁氨基激酶抑制剂

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