改善初级渐进性失言症患者语言和沟通的非药物干预措施
Mandy Roheger1, Steffen Riemann2, Andreas Brauer2
1Department of Psychology, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
The Cochrane database of systematic reviews
|May 29, 2024
概括
与语言治疗相结合的跨直流刺激 (tDCS) 等非药物干预措施显示,在初级渐进性失言症 (PPA) 中改善词汇检索的潜力. 然而,目前的证据的确定性非常低,需要进一步进行高质量的研究.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 神经康复疗法 神经康复疗法
背景情况:
- 初级渐进性失语症 (PPA) 是一种神经退行性疾病,其特点是语音和沟通能力逐渐下降,占前性痴呆症的很大一部分.
- 目前,PPA没有治愈方法,强调需要进行干预来管理症状并改善生活质量.
研究的目的:
- 评估针对PPA患者的非药物干预措施的有效性.
- 主要结果包括词汇检索的改善,以及对全球语言功能,认知,生活质量和不良事件的评估.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查,搜索多个数据库,直到2024年1月.
- 包括的研究评估了非药物干预措施,如横直流刺激 (tDCS),重复性横磁刺激 (rTMS) 和各种语言训练疗法,单独或组合.
主要成果:
- 纳入了10项涉及132名参与者的研究. 单词检索的结果是混合的,证据的确定性非常低.
- 与行为语言治疗结合活性tDCS,与假刺激相比,对训练项目的词检索立即有所改善.
- 对未经训练的项目,长期维护,全球语言,认知和生活质量的影响的证据有限,确定性非常低.
结论:
- 目前缺乏高确定性证据来指导对PPA非药物治疗的临床决策.
- 初步发现表明,tDCS与语言疗法结合用于词检索的语言疗法的潜在好处,但进一步的高质量的RCT是必不可少的.
- 未来的研究应该专注于详细的方法,多样化的结果 (包括生活质量),以及针对不同PPA亚型的个性化治疗方法.
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